121082-84-6 → HCID 15158299, compound

HRID 2253663Notes

Reaction equation

HRID 2253663 reaction equation
[NH2:1][CH2:2][CH:3]1[O:7][C:6](=[O:8])[N:5]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:4]1.Cl[CH2:16][CH2:17][CH:18]([C:22]1[CH:27]=[CH:26][C:25]2[O:28][CH2:29][O:30][C:24]=2[CH:23]=1)[CH2:19][CH2:20]Cl>CC(C)=O.O>[C:9]1([N:5]2[CH2:4][CH:3]([CH2:2][N:1]3[CH2:16][CH2:17][CH:18]([C:22]4[CH:27]=[CH:26][C:25]5[O:28][CH2:29][O:30][C:24]=5[CH:23]=4)[CH2:19][CH2:20]3)[O:7][C:6]2=[O:8])[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

Participants

5

Reactant 2

HCID 15158297121082-84-6HCID 15158298HCID 15158298, compound

Product 1

HCID 15158299HCID 15158299, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 962WaterSolvent

Procedure

A mixture of 1.92 g of 5-aminomethyl-3-phenyloxazolidin-2-one [obtainable by reaction of 5-chloromethyl-3-phenyloxazolidin-2-one with potassium phthalimide and subsequent hydrolysis] and 2.63 g of 1,5-dichloro-3-(3,4-methylenedioxyphenyl)pentane in 40 ml of acetone and 40 ml of water is boiled for 24 hours and worked up as usual, giving 3-phenyl-5-[4-(3,4-methylenedioxyphenyl)piperidinomethyl]oxazolidin-2-one.

Sources & evidence

ORD record
ord-8d55f09228b341dabc515a2169cd2482
Source dataset
uspto-grants-1993_08
Patent number
US05232931

Reaction notes

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