HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → 3-[2-[4-(4-Fluorobenzoyl)piperidin-1-yl]ethyl]-7,8-dihydro-2H,6H-pyrrolo[1,2-a]-1,3,5-triazine-2,4(3H)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | ethyl N-ethoxycarbonyliminocarbamate | HCID 220568 | — |
| Reactant | 7,8-Dihydropyrrolo[1,2-a][1,3,5]triazine-2,4(3H,6H)-dione | HCID 10397016 | — |
| Reactant | 4-(4-Fluorobenzoyl)-1-(2-hydroxyethyl)piperidine | HCID 14892165 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-[2-[4-(4-Fluorobenzoyl)piperidin-1-yl]ethyl]-7,8-dihydro-2H,6H-pyrrolo[1,2-a]-1,3,5-triazine-2,4(3H)-dione | HCID 15105374 | — |
Reaction Steps
In the manner described in Example 1-2), 7,8-dihydro-2H,6H-pyrrolo[1,2-a]-1,3,5-triazine-2,4(3H)-dione prepared in 1) above and 4-(4-fluorobenzoyl)-1-(2-hydroxyethyl)piperidine were condensed in N,N-dimethylformamide in the presence of triphenylphosphine and diethyl azodicarboxylate to obtain the entitled compound as a caramel-like substance.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05232924 |
| Source dataset | uspto-grants-1993_08 |
| ORD ID | ord-feb9c48662a14f1c8735b058f8bd9db9 |
| Source note | uspto-grants-1993_08 |