HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → 3-[2-Phenyl-2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-6,7,8,9-tetrahydro-2H-pyrido[1,2-a]-1,3,5-triazine-2,4(3H)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | ethyl N-ethoxycarbonyliminocarbamate | HCID 220568 | — |
| Reactant | 6,7,8,9-Tetrahydropyrido[1,2-a][1,3,5]triazine-2,4-dione | HCID 15105369 | — |
| Reactant | 4-(4-Fluorobenzoyl)-1-(1-phenyl-2-hydroxyethyl)piperidine | HCID 19746036 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-[2-Phenyl-2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-6,7,8,9-tetrahydro-2H-pyrido[1,2-a]-1,3,5-triazine-2,4(3H)-dione | HCID 19746037 | — |
Reaction Steps
In the manner described in Example 1-2), 6,7,8,9-tetrahydro-2H-pyrido[1,2-a]-1,3,5-triazine-2,4(3H)-dione obtained in Example 1-1) and 4-(4-fluorobenzoyl)-1-(1-phenyl-2-hydroxyethyl)piperidine were condensed in N,N-dimethylformamide in the presence of triphenylphosphine and diethyl azodicarboxylate to obtain the entitled compound as a colorless oily substance.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05232924 |
| Source dataset | uspto-grants-1993_08 |
| ORD ID | ord-69bd8227ac324f3e97ad4f97abb779b4 |
| Source note | uspto-grants-1993_08 |