Sodium Iodide → HCID 15105344, compound

Participants

Reaction Steps

2-(2-Chloroethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one (26.8 g), 31.5 g of sodium iodide and 400 mλ of acetonitrile were refluxed for 30 minutes. To the reaction mixture were added 38.2 g of 4-[bis(4-fluorophenyl)methylene]piperidine and 27.6 g of potassium carbonate, followed by heating at reflux for 8 hours. The insoluble material was removed by filtration, and the filtrate was concentrated to dryness under reduced pressure. The residue was dissolved in 200 mλ of chloroform, and the solution was applied to a column contained with 550 g of silica gel and eluted with chloroform to obtain 53.0 g of the entitled compound as an oily substance.

Provenance & Evidence