Sodium Hydroxide → HCID 14801248, compound

Participants

Reaction Steps

870 mg (5.0 mmole) of methyl N-ethyl-N-n-propyloxamate was dissolved in 20 ml of methanol. The resulting mixture was stirred under ice-cooling over an ice bath. 594 mg (15 mmole) of sodium hydroxide was dissolved in 10 ml of water and the resulting solution was added dropwise to said mixture. After completion of the dropwise addition, the ice bath was removed and the reaction mixture was stirred for 1 hour at room temperature. After adding 10 ml of 1N aqueous solution of hydrochloric acid, the solvent was distilled off from the reaction solution under reduced pressure. The residue was added with 80 ml of ethanol and the insoluble solids as formed were filtered off. The organic solution after the filtration was concentrated to afford 305 mg (1.9 mmole) of N-ethyl-N-n-propyloxamic acid as a colorless oil.

Provenance & Evidence