Ethyl Lactate → HCID 54142872, compound

Participants

Reaction Steps

At 0° C., 0.1 mol of DCC, dissolved in methylene chloride, is added with exclusion of moisture to a mixture of 0.1 mol of pentanoic acid, 0.1 mol of optically active 2-(4'-heptyloxy-2,3-difluorobiphenyl-4-oxy)propan-1-ol (prepared by reduction of the corresponding ethyl lactate using LiBH4) and a catalytic amount of DMAP in 250 ml of methylene chloride. The mixture is subsequently stirred at room temperature for 12 hours, the precipitate is filtered off with suction, and the filtrate is worked up in a customary manner, to give optically active 4'-heptyloxy-2,3-difluoro-4-(1-valeroyloxy-2-propyloxy)biphenyl.

Provenance & Evidence