Triphenylphosphine → HCID 19745625, compound

Participants

Reaction Steps

0.05 mol of methyl 2,3-difluoro-4-hydroxybenzoate, 0.05 mol of (S)-2-fluorooctan-1-ol and 0.06 mol of triphenylphosphine are dissolved in 125 ml of tetrahydrofuran, and 0.06 mol of diethyl azodicarboxylate is added dropwise with stirring and ice cooling. The mixture is allowed to warm to room temperature and is stirred for a further 8 hours. The solvent is then removed by distillation, and the methyl 2,3-difluoro-4-(2-fluorooctyloxy)benzoate is purified by column chromatography. 2,3-Difluoro-4-(2-fluorooctyloxy)benzoic acid is obtained therefrom by hydrolysis using aqueous/alcoholic potassium hydroxide solution.

Provenance & Evidence