o-Toluenesulfonyl chloride → HCID 67878066, compound

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Reaction Steps

0.02 mol of 2,3-difluoro-4-hydroxy-4'-pentyl-p-terphenyl, 0.02 mol of potassium carbonate and 0.2 mol of (S)-2-fluorooctyl p-toluenesulfonate (prepared from (S)-2-fluorooctan-1-ol and toluenesulfonyl chloride in the presence of pyridine) are stirred at 60° for 15 hours in 25 ml of dimethylformamide. The undissolved salts are filtered off with suction, and water is added to the filtrate. Extractive work-up and subsequent column chromatography give the pure (S)-2,3-difluoro-4-(2-fluorooctyloxy)-4'-pentyl-p-terphenyl.

Provenance & Evidence