Sodium Hydroxide → HCID 54179475, compound

HRID 2253726Notes

Reaction equation

HRID 2253726 reaction equation
[C:1]([CH2:5][C:6]1[CH:11]=[C:10]([O:12][CH2:13][CH:14]=[CH:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:9]=[C:8]([CH2:22][C:23]([O:25]C)=[O:24])[CH:7]=1)([O:3]C)=[O:2].[OH-].[Na+]>CCO>[C:23]([CH2:22][C:8]1[CH:9]=[C:10]([O:12][CH2:13][CH:14]=[CH:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:11]=[C:6]([CH2:5][C:1]([OH:3])=[O:2])[CH:7]=1)([OH:25])=[O:24]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 53945861HCID 53945861, compound

Product 1

HCID 54179475HCID 54179475, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 2.98 g (8.82 mmoles) of 1,3-di-(carbomethoxymethyl)-5-cinnamyloxybenzene in 50 ml EtOH is added 26 ml of 1N NaOH. After 12 hours, the reaction mixture is concentrated down in vacuo, taken up in H2O and acidified to pH 4 with 1N HCl. The solid precipitate is collected and recrystallized from MeOH to afford 1,3-di-(carboxymethyl)-5-cinnamyloxybenzene which is used directly in the next step.

Workup

  1. concentrationthe reaction mixture is concentrated down in vacuo
  2. customThe solid precipitate is collected
  3. customrecrystallized from MeOH

Sources & evidence

ORD record
ord-5bf13fa607da4730acf1190b46f5169f
Source dataset
uspto-grants-1993_08
Patent number
US05232948

Reaction notes

Loading…