HRID225373

反应详情

EQUATION

反应方程式

REACTANTS

反应物

$结构：CC#CCC(C)(C)[C@@H](/C=C/[C@H]1CCC(=O)[C@@H]1C/C=C\CCCC(=O)O)OC1CCCCO1$

HCID70588635

未命名化合物

PRODUCTS

生成物

$结构：CC#CCC(C)(C)[C@H](O)/C=C/[C@H]1CCC(=O)[C@@H]1C/C=C\CCCC(=O)O$

HCID70588415

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID21877175

未命名化合物

PROCEDURE

实验过程

At 20°, 390 mg. of (5Z,13E)-(15R)-16,16-dimethyl-9-oxo-15-(tetrahydropyran-2-yloxy)-5,13-prostadien-18-ynoic acid is agitated for 16 hours with 10 ml. of a mixture of glacial acetic acid/water/THF (65/35/10); the mixture is evaporated under vacuum and the residue purified by column chromatography on silica gel. With methylene chloride/5% methanol, 305 mg. of the title compound is obtained as a colorless oil.

WORKUP

后处理

customAt 20°
customthe mixture is evaporated under vacuum
customthe residue purified by column chromatography on silica gel