反应详情

To a solution of ethyl 3,5-dibenzyloxyphenylacetate (4.1 g, 10.9 mmol) in 50 ml of EtOH is added 21 ml (6 eq) of 1N NaOH. The reaction is stirred at room temperature for 2 hours at which time it is extracted with Et2O and H2O. The H2O layer is acidified to pH~1 using 1N HCl and extracted with Et2O. The organics are dried (MgSO4) and concentrated in vacuo to obtain 3,5-dibenzyloxyphenylacetic acid which is confirmed by NMR and used directly in the next step.

1. extractionis extracted with Et2O and H2O
2. extractionextracted with Et2O
3. dry with materialThe organics are dried (MgSO4)
4. concentrationconcentrated in vacuo