N-Methylbenzeneethanamine → HCID 10646909, compound

Participants

Reaction Steps

To a solution of 1.85 g (5.69 mmoles) of cis-3-carbomethoxyvinyl-4-benzyloxyphenylacetic acid in 50 ml of CH2Cl2 is added 1.02 g (6.26 mmoles) if 1,1'-carbonyldiimadazole. After 15 minutes, 827 ml (5.69 mmoles) of N-methyl-N-phenethylamine is added. After 5 hours, the reaction mixture is concentrated in vacuo and is purified flash chromatography to yield cis-N-methyl-N-phenethyl-2-[4-benzyloxy-3-(2-carbomethoxyvinyl)phenyl]acetamide which is used directly in the next step.

Provenance & Evidence