HuagongsheHuagongshe Chemistry Print Report · For research reference only
Citric Acid → L 674573
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Citric Acid | HCID 311 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | {[4-Phenyl-1-(4-(2-quinolinylmethoxy)phenyl)butyl]thio}acetic acid, methyl ester | HCID 86745621 | — |
| Solvent | MeOH tetrahydrofuran | HCID 21899815 | — |
| Product | L 674573 | HCID 124437 | — |
Reaction Steps
To a solution of the ester (Step III) in 20 mL of THF/MeOH (1:1) was added NaOH (6 mL, 1M). After 1 h at RT, the reaction was acidified with aqueous citric acid and the organic phase was partially evaporated. The solid was filtered off, washed with water and recrystallized from ethyl acetate/hexane to afford the title compound. m.p. 141°-143°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05232916 |
| Source dataset | uspto-grants-1993_08 |
| ORD ID | ord-e1edc9063f92439286ba6bf25625922c |
| Source note | uspto-grants-1993_08 |