HCID 70588280, compound → HCID 70588193, compound

Participants

Reaction Steps

320 mg. of (5Z,13E)-(15S)-9-oxo-15-(tetrahydropyran-2-yloxy)-5,13-prostadien-18-ynoic acid is agitated for 16 hours at room temperature with 8 ml. of a mixture of glacial acetic acid/water/THF (65/35/10), then evaporated under vacuum, and the residue purified by column chromatography on silica gel. With methylene chloride/5% methanol, 210 mg. of the title compound is obtained as a colorless oil.

Provenance & Evidence