HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl Thioglycolate → Methyl ((4-(4-chlorophenyl)-1-(4-hydroxyphenyl)-1-butyl)thio)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl Thioglycolate | HCID 16907 | — |
| Reactant | 4-(4-(4-Chlorophenyl)-1-hydroxybutyl)phenol | HCID 19745872 | — |
| Catalyst | zinc(II)iodide | HCID 9883512 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl ((4-(4-chlorophenyl)-1-(4-hydroxyphenyl)-1-butyl)thio)acetate | HCID 54384776 | — |
Reaction Steps
To a suspension of the alcohol (0.23 g) (Step VI) in CH2Cl2 (5 mL) and methyl thioglycolate (80 μL) was added ZnI2 (10 mg). The mixture was stirred 2 hrs, buffer (pH 7) was added. The mixture was extracted with ethyl acetate, which was dried and evaporated. Flash chromatography using 5% ethyl acetate in toluene afforded the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05232916 |
| Source dataset | uspto-grants-1993_08 |
| ORD ID | ord-d8633e2412724c49b74225f7a8783f4f |
| Source note | uspto-grants-1993_08 |