1-(3-Bromopropyl)-4-chlorobenzene → 4-(4-Chlorophenyl)-1-(4-t-butyldiphenylsiloxy phenyl)butanol

HRID 2253755Notes

Reaction equation

HRID 2253755 reaction equation
Br[CH2:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][CH:6]=1.[CH3:12][C:13]([Si:16]([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[O:17][C:18]1[CH:25]=[CH:24][C:21]([CH:22]=[O:23])=[CH:20][CH:19]=1)([CH3:15])[CH3:14]>>[CH3:15][C:13]([Si:16]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)([C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=1)[O:17][C:18]1[CH:25]=[CH:24][C:21]([CH:22]([OH:23])[CH2:2][CH2:3][CH2:4][C:5]2[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][CH:6]=2)=[CH:20][CH:19]=1)([CH3:12])[CH3:14]

Participants

3

Reactant 2

HCID 98811361-(3-Bromopropyl)-4-chlorobenzeneHCID 114283834-((2-Methyl-2-propyl)diphenylsilyloxy)benzaldehyde

Product 1

HCID 538578064-(4-Chlorophenyl)-1-(4-t-butyldiphenylsiloxy phenyl)butanol

Procedure

Using the procedure of Example 1, Step 2, the Grignard reagent prepared from 1-(3-bromopropyl)-4-chlorobenzene was added to the benzaldehyde of Step 1. The title compound so obtained was used as such in the next step.

Sources & evidence

ORD record
ord-ebd7a9a97f734258981d4506e593cc07
Source dataset
uspto-grants-1993_08
Patent number
US05232916

Reaction notes

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