HCID 70589709, compound → HCID 70588333, compound

Participants

Reaction Steps

300 mg. of (5Z,13E)-(15RS)-15-methyl-9-oxo-15-(tetrahydropyran-2-yloxy)-5,13-prostadien-18-ynoic acid is agitated for 16 hours at room temperature with 8 ml. of a mixture of glacial acetic acid/water/THF (65/35/10); the mixture is then evaporated under vacuum, and the residue is purified by chromatography on silica gel. With methylene chloride/5% methanol, 205 mg. of the title compound is obtained as a colorless oil.

Provenance & Evidence