HCID 70589842, compound → HCID 70588256, compound

Participants

Reaction Steps

A solution of 450 mg. of (5Z,13E)-(11R,15RS)-11,15-dimethyl-9-oxo-15-(tetrahydropyran-2-yloxy)-5,13-prostadien-18-ynoic acid in 15 ml. of a mixture of glacial acetic acid/water/THF (65/35/10) is agitated for 16 hours at 25°. After evaporating the solvent under vacuum, the remainder is purified by chromatography on silica gel. By elution with methylene chloride containing 1-5% methanol, 305 mg. of the title compound is isolated in the form of an oil.

Provenance & Evidence