HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → 3alpha-N-methyl-nicotinoyloxy,5alpha-pregnan-20-one iodide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | 3alpha-Nicotinoyloxy-5alpha-pregnan-20-one | HCID 54438032 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 3alpha-N-methyl-nicotinoyloxy,5alpha-pregnan-20-one iodide | HCID 131718039 | — |
Reaction Steps
A mixture of 3α-nicotinoyloxy-5α-pregnan-20-one (770 mg, 421 g/m, 1.8 mmol) and methyliodide (3.0 mL, 141 g/m, ~20 mmol) in 30 mL of acetone was refluxed gently for 17 hours. The reaction mixture was concentrated in vacuo to give the crude product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05232917 |
| Source dataset | uspto-grants-1993_08 |
| ORD ID | ord-634b2869ce3a45c5bcef2c451e0fa89d |
| Source note | uspto-grants-1993_08 |