HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 86747082, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethanamine, 2-chloro-N-methyl- | HCID 20652 | — |
| Reactant | HCID 9990714 | HCID 9990714 | — |
| Reactant | [2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl]-N-methyl-N-(2-bromoethyl)phosphoramidoyl chloride | HCID 86747081 | — |
| Product | HCID 86747082 | HCID 86747082 | 61% |
Reaction Steps
This compound was prepared from N-methyl-N-chloroethylamine.HCl via N-methyl-N-(2-chloroethyl)phosphoramidic dichloride, as described for 16a (14 mmol scale). The crude residue was purified by chromatography (1:4 EtOAc:hexanes) to give 16b as an oil (2.72 g, 61%): Rf 0.75 (1:1 EtOAc:hexanes); 1H NMR (CDCl3) 4.22(m, 4H), 3.60(m, 3H), 3.42(m, 2H), 2.80(d, 3H, J=12.85 Hz), 1.99(dt, 2H, J=6.11 Hz), 1.36(d, 6H, J=15.82 Hz)ppm; -P NMR (CDCl3) -7.69, -7.92 ppm (1:1 ratio of diastereomers).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05233031 |
| Source dataset | uspto-grants-1993_08 |
| ORD ID | ord-9ae7fd4e9b2f4e48bcba8125ed132991 |
| Source note | uspto-grants-1993_08 |