HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen iodide → HCID 86747083, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen iodide | HCID 24841 | — |
| Reactant | HCID 10447621 | HCID 10447621 | — |
| Reactant | (2-Iodoethyl)(methyl)amine | HCID 17138990 | — |
| Reactant | [2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl]-N-methyl-N-(2-bromoethyl)phosphoramidoyl chloride | HCID 86747081 | — |
| Product | HCID 86747083 | HCID 86747083 | 61% |
Reaction Steps
This compound was prepared using N-methyl-N-2-iodoethylamine.HI via N-methyl-N-(2-iodoethyl)phosphoramidic dichloride, as described for 16a (10 mmol scale). The crude product was purified by chromatography (1:4 EtOAc:hexanes) which afforded 16c as a pale yellow oil (2.50 g, 61%): Rf 0.67 (1:1 EtOAc:hexanes); 1H NMR (CDCl3) 4.27(m, 3H), 4.10(t, 1H, J=6.52 Hz), 3.59(t, 1H, J=7.38 Hz), 3.44(m, 2H), 3.26(t, 2H, J=7.56 Hz), 2.78(d, 3H, J=12.89 Hz), 2.00(dt, 2H, J=6.02 Hz), 1.38(d, 6H, J=15.48 Hz)ppm; 31P NMR (CDCl3) -8.46, -8.69 ppm (1:1 ratio of diastereomers).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05233031 |
| Source dataset | uspto-grants-1993_08 |
| ORD ID | ord-a33c053cce7b4acbbb67d521c10d9766 |
| Source note | uspto-grants-1993_08 |