3,4,6-Trifluoro-5-hydroxyphthalic acid → 2,4,5-Trifluoro-3-hydroxybenzoic Acid

HRID 2253936Notes

Reaction equation

HRID 2253936 reaction equation
[F:1][C:2]1[C:10]([OH:11])=[C:9]([F:12])[C:8]([F:13])=[C:4](C(O)=O)[C:3]=1[C:14]([OH:16])=[O:15]>O>[F:1][C:2]1[C:10]([OH:11])=[C:9]([F:12])[C:8]([F:13])=[CH:4][C:3]=1[C:14]([OH:16])=[O:15]

Participants

3

Reactant 1

HCID 101985873,4,6-Trifluoro-5-hydroxyphthalic acid

Product 1

HCID 27342702,4,5-Trifluoro-3-hydroxybenzoic Acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Japanese Patent Application 86/290399 as abstracted in CA109 (19) 170038e discloses that 3,5,6-trifluoro-4-hydroxyphthalic acid may be decarboxylated by heating the compound for three hours, in water, under nitrogen atmosphere, at 140° C. (in a sealed tube) to yield 2,4,5-trifluoro-3-hydroxybenzoic acid.

Workup

  1. temperatureby heating the compound for three hours

Sources & evidence

ORD record
ord-019865582e27403aad1e81f7ae7d6384
Source dataset
uspto-grants-1993_08
Patent number
US05233085

Reaction notes

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