反应详情

2-(5-Tert-butyloxycarbonylamino-1,2,4-thiadiazol-3-yl)-2-oxoacetic acid (3.0 g) was dissolved in methanol (30 ml). To this solution a solution of tert-butyl 2-aminooxy-2-(methylthio)acetate (2.12 g) in methanol (20 ml) was added dropwise. The resultant mixture was stirred for 1 hr. at the room temperature, and then the solvent was evaporated to give (Z)-2-(5-tert-butyloxycarbonylamino-1,2,4-thiadiazol-3-yl)-2-[[(tert-butoxycarbonyl)(methylthio)methoxy]imino]acetic acid (2.42 g).

1. customat the room temperature, and then the solvent was evaporated