Hydrochloric Acid → HCID 19744031, compound

Participants

Reaction Steps

Into 280 ml of concentrated hydrochloric acid and 140 ml of acetic acid were suspended 18.0 g of ethyl 1-(4-bromo-2-fluorophenyl)methyl-6-chloro-1,4-dihydro-2,4-dioxo-3(2H)quinazolineacetate, and, after added 1 ml of concentrated sulfuric acid, the mixture was refluxed for 3 hours. After cooling, the reaction liquor was poured into 600 ml of ice water and the deposits were collected by filtration. They were recrystallized from ethanol to obtain 15.0 g of title compound. m.p. 189° C.

Provenance & Evidence