Potassium Hydroxide → HCID 19744068, compound

Participants

Reaction Steps

Into 50 ml of ethanol were dissolved 1.59 g of ethyl 6-chloro-1-(4-fluorophenyl)methyl-1,4dihydro-2,4-dioxo-3(2H)-quinazolineacetate, and after added 5 ml of aqueous solution containing 0.30 g of potassium hydroxide, the mixture was refluxed for 1 hour. After cooling by allowing to stand, ethanol was distilled off and the residue was dissolved by adding 30 ml of water, acidified with concentrated hydrochloric acid, and the deposits were collected by filtration. They were recrystallized from acetonitrile to obtain 0.75 g of title compound. m.p. 211°-212° C.

Provenance & Evidence