Sodium Hydroxide → HCID 19744048, compound

Participants

Reaction Steps

Into 50 ml of ethanol were dissolved 2.0 g of ethyl 1-(2,4-dichlorophenyl)methyl-1,4-dihydro-2,4-dioxo-6-fluoro-7-imidazolyl-3(2H)-quinazolineacetate, and, after added 4.5 ml of 1N aqueous solution of sodium hydroxide, the mixture was refluxed for 1.5 hours. Ethanol was distilled off, water was added, pH was made to be 5 with 3N hydrochloric acid, and the deposits were collected by filtration. They were recrystallized from dioxane to obtain 930 mg of title compound. m.p. 188°-189° C.

Provenance & Evidence