反应详情

温度

40 °C

To 25 mL of DMSO was added 4.5 g of 5-bromo-4-chloro-5,6,7,8-tetrahydro-2-trifluoromethylquinazoline and 4.7 g of anhydrous sodium acetate. The reaction mixture was warmed for 2 hours at which time 4.1 g of N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]amine hydrochloride was added and the reaction was heated to 40° C. overnight. To the crude reaction mixture was added 24 mL of 2.5N aqueous sodium hydroxide. After 1 hour the reaction was diluted with 500 mL of water and was acidified with hydrochloric acid. The acidified reaction mixture was extracted with ethyl acetate and the organic fractions were washed with brine, dried over anhydrous magnesium sulfate, filtered and evaporated. The resulting residue was purified on silica to yield 5.3 g of the title product: 1H NMR (DMSO-d6, 400 MHz) δ 7.80 (m, 1H), 7.60 (m, 2H), 7.48 (m, 2H), 7.28 (m, 2H), 7.03 (m, 2H), 5.33 (bs, 1H), 4.63 (m, 3H), 2.60 (m, 3H), 1.80 (m, 3H); positive DCI MS m/e 468(M+H); 506(M+K). Anal. calc'd for C23H20F3N7O.2H2O: C, 54.87; H, 4.80; N, 19.48. Found: C, 54.52; H, 4.44; N, 18.14.

1. additionwas added
2. customTo the crude reaction mixture
3. customThe acidified reaction mixture
4. extractionwas extracted with ethyl acetate
5. washthe organic fractions were washed with brine
6. dry with materialdried over anhydrous magnesium sulfate
7. filtrationfiltered
8. customevaporated
9. customThe resulting residue was purified on silica