HCID 54307582, compound → HCID 15170365, compound

HRID 2254131Notes

Reaction equation

HRID 2254131 reaction equation
[Br:1][C:2]1[CH:18]=[CH:17][C:5]([CH:6]=[C:7]([C:14]([CH3:16])=O)[C:8]([O:10][CH2:11][CH2:12][CH3:13])=[O:9])=[CH:4][CH:3]=1.[CH3:19][NH:20]/[C:21](/[CH3:29])=[CH:22]\[C:23]([O:25][CH2:26][CH2:27][CH3:28])=[O:24]>CC(O)CC>[Br:1][C:2]1[CH:18]=[CH:17][C:5]([CH:6]2[C:22]([C:23]([O:25][CH2:26][CH2:27][CH3:28])=[O:24])=[C:21]([CH3:29])[N:20]([CH3:19])[C:14]([CH3:16])=[C:7]2[C:8]([O:10][CH2:11][CH2:12][CH3:13])=[O:9])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 54307582HCID 54307582, compoundHCID 86747093HCID 86747093, compound

Product 1

HCID 15170365HCID 15170365, compound

Reagents, catalysts & solvents 1

HCID 6568(+-)-2-ButanolSolvent

Procedure

A solution of 6.22 g (0.02 mol) of propyl 2-(4-bromobenzylidene)acetoacetate and 3.14 g (0.02 mol) of propyl 3-methylamino-crotonate in 25 ml of 2-butanol is stirred under reflux for 10 hours. The mixture is then concentrated in vacuo, and the precipitate formed in the cold is filtered off with suction. After recrystallization from propanol, 5.32 g (59.1% of theory) of melting point 97°-99° C. are obtained.

Workup

  1. temperatureunder reflux for 10 hours
  2. concentrationThe mixture is then concentrated in vacuo
  3. customthe precipitate formed in the cold
  4. filtrationis filtered off with suction
  5. customAfter recrystallization from propanol, 5.32 g (59.1% of theory) of melting point 97°-99° C.
  6. customare obtained

Sources & evidence

ORD record
ord-841a8a693a59436da525fa8bef0d8df2
Source dataset
uspto-grants-1993_08
Patent number
US05234935

Reaction notes

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