Ammonia → HCID 19009986, compound

Participants

Reaction Conditions

Reaction Steps

In a 7% ammonia solution in methanol were dissolved 2.6 g of o-trifluoromethylbenzaldehyde and 5.8 g of benzyl acetoacetate, and the solution was stirred in a closed tube at 90° C. for 10 hours. The reaction mxiture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (methanol/dichloromethane =1/50) to obtain 6.0 g (yield: 76%) of dibenzyl 1,4-dihydro -2,6-dimethyl-4-(2-trifluoromethylphenyl)-3,5-pyridinedicarboxylate as a yellow oily substance.

Provenance & Evidence