HRID2254179

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7012

Benzeneacetic acid, .alpha.-ethyl-

C10H12O2

HCID609328

2,3,5-Trimethyl-6-nitroindole

C11H12N2O2

结构：COC(=O)c1ccc(Cn2c(C)c(C)c3cc(C)c(N)cc32)c(OC)c1

HCID19744303

未命名化合物

PRODUCTS

生成物

结构：CCC(C(=O)Nc1cc2c(cc1C)c(C)c(C)n2Cc1ccc(C(=O)OC)cc1OC)c1ccccc1

HCID19744308

未命名化合物

收率 32%

PROCEDURE

实验过程

Similarly, starting from methyl 4-(6-amino-2,3,5-trimethylindol-1-ylmethyl)-3-methoxybenzoate (itself obtained using the procedures described for A in Example 1 but starting from 2,3,5-trimethyl-6-nitroindole [G]) and 2-phenylbutyric acid, there was obtained methyl 3-methoxy-4-[2,3,5-trimethyl-6-(2-phenylbutanamido)indol-1-ylmethyl]-benzoate [Example 83] in 32% yield as a white solid; partial NMR: 0.9 (t,3H,CH2CH3), 1.2 (m,2H, CH2CH3), 3.4 (t,1H,CHPh), 7.3 (s,5H,Ph).

WORKUP

后处理

customobtained

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f4db26dc5711413f8036dfd2397babf3
来源数据集: uspto-grants-1993_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05234942
来源说明: uspto-grants-1993_08

反应 SMILES

[NH2:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:25])=[C:7]([CH3:24])[N:8]2[CH2:11][C:12]2[CH:21]=[CH:20][C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:14][C:13]=2[O:22][CH3:23])=[CH:4][C:3]=1[CH3:26].CC1NC2C(C=1C)=CC(C)=C([N+]([O-])=O)C=2.[C:42]1([CH:48]([CH2:52][CH3:53])[C:49](O)=[O:50])[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1>>[CH3:23][O:22][C:13]1[CH:14]=[C:15]([CH:20]=[CH:21][C:12]=1[CH2:11][N:8]1[C:9]2[C:5](=[CH:4][C:3]([CH3:26])=[C:2]([NH:1][C:49](=[O:50])[CH:48]([C:42]3[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=3)[CH2:52][CH3:53])[CH:10]=2)[C:6]([CH3:25])=[C:7]1[CH3:24])[C:16]([O:18][CH3:19])=[O:17]