4-Hydroxybenzaldehyde → Benzaldehyde, 4-(phenylmethoxy)-

Participants

Reaction Steps

In 200 ml of anhydrous dimethylformamide was dissolved 30.0 g of p-hydroxybenzaldehyde, and 40.9 g of anhydrous potassium carbonate was added to the solution and the mixture was stirred at room temperature for 30 minutes. Then, 46.3 g of benzyl bromide was dropped into the mixture and a reaction was carried out at room temperature with stirring overnight. After the reaction, the reaction mixture was extracted with diethyl ether, and the solvent was removed from the extract by distillation. The obtained residue was recrystallized from a mixed solvent of diethyl ether and n-hexane to obtain 48.2 g (yield=92.3%) of p-benzyloxybenzaldehyde in the form of a colorless prism.

Provenance & Evidence