Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 1-(Phenylsulfonyl)-4-piperazin-1-yl-1H-indole Hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | t-butyl 4-(1-benzenesulfonyl-1H-indol-4-yl)piperazine-1-carboxylate | HCID 22015366 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 1-(Phenylsulfonyl)-4-piperazin-1-yl-1H-indole Hydrochloride | HCID 10270968 | 99% |
반응 단계
A portion of the t-butyl 4-(1-benzenesulfonyl-1H-indol-4-yl)piperazine-1-carboxylate (0.85 g) is stirred in a mixture of 4N HCl and dioxane at room temperature for 2 hrs and filtered. The filtercake is dried to give the title product as a while solid, 0.64 g (99% yield) mp 60° C. identified by mass spectral and NMR analyses.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07557098B2 |
| 출처 데이터셋 | uspto-grants-2009_07 |
| ORD ID | ord-b03a5db651ec40d3bbfb5d7f0db51248 |
| 출처 메모 | uspto-grants-2009_07 |