HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 225426Generated: October 27, 2026
Diisopropylethylamine → 4-[4-(4,5-Dihydro-1H-imidazol-2-yl)-piperazin-1-yl]-1-(phenylsulfonyl)-1H-indole
https://huagongshe.com/reaction/225426
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1-(Phenylsulfonyl)-4-(1-piperazinyl)-1h-indole | HCID 10154392 | — |
| Reactant | 1H-Imidazole, 4,5-dihydro-2-(methylthio)-, hydriodide (1:1) | HCID 12221228 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-[4-(4,5-Dihydro-1H-imidazol-2-yl)-piperazin-1-yl]-1-(phenylsulfonyl)-1H-indole | HCID 22174821 | — |
Reaction Steps
A solution of 1-(phenylsulfonyl)-4-piperzin-1-yl-1H-indole (71 mg, 0.18 mmol) in dioxane is treated with 2-methylthio-2-imidazoline hydroiodide (52.7 mg, 0.22 mmol) and N,N-diisopropylethylamine (62 μl, 0.36 mmol), heated at 50° C. for 16 hr., cooled and concentrated in vacuo to give a residue. The residue is purified by HPLC to give the title product, 15 mg, identified by HPLC and mass spectral analyses (2.57 min; 410 M+H) using the LCMS conditions described in Table I.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07557098B2 |
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| Source dataset | uspto-grants-2009_07 |
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| ORD ID | ord-34dc52177d7e4b9b837d853360c2c0c0 |
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| Source note | uspto-grants-2009_07 |
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