HCID 19744865, compound → Benzaldehyde, 4-(phenylmethoxy)-

Participants

Reaction Steps

In 65 ml of dimethylsulfoxide were dissolved 20.01 g of the 4'-benzyloxy-2'-hydroxy-3'-(3-methyl-2butenyl)acetophenone obtained in Production Example 15 and 15.00 g of the 4-benzyloxybenzaldehyde obtained in Production Example 27, and 130 ml of a saturated ethanol solution of potassium hydroxide was added to the solution and the mixture was stirred at room temperature in a nitrogen current for 2.5 hours. After the reaction, the reaction liquid was diluted with water and was gradually made acidic by addition of 3 N hydrochloric acid under cooling. The formed precipitate was recovered by filtration and recrystallized from a mixed solvent of benzene and ethanol to obtain 23.64 g (yield=72.7%) of 4,4'-dibenzyloxy-2'-hydroxy-3+-(3-methyl-2-butenyl)chalcone in the form of a yellow needle.

Provenance & Evidence