Methyl L-phenylalaninate hydrochloride → HCID 67858686, compound

Participants

Reaction Steps

The procedure of Example 12 (ii-iii) was followed using L-phenylalanine methyl ester hydrochloride in place of glycine methyl ester hydrochloride. From 5.59 g (16.3 mmol) of 2-[2-n-butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]acetic acid hydrochloride, there was obtained 6.88 g (90%) of the intermediate N-[{2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazol-5-yl}methylcarbonyl]-L-phenylalanine methyl ester; mp 88°-90° C. (from ethanol/water). Hydrolysis of this ester provided the title compound in a 79% yield; mp 168°-170° C.; [α]25 (c=1, methanol).

Provenance & Evidence