Methyl L-phenylalaninate hydrochloride → HCID 67858636, compound

HRID 2254294Notes

Reaction equation

Cl.C[O:3][C:4](=[O:14])[C@H:5]([CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[NH2:6].[CH2:15]([C:19]1([CH3:36])[NH:23][C:22]([Cl:24])=[C:21]([CH2:25][C:26](O)=[O:27])[N:20]1[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[Cl:35])[CH2:16][CH2:17][CH3:18].ClC1C=CC=CC=1CN1C(C(O)=O)=CN=C1SCCC>>[CH2:15]([C:19]1([CH3:36])[NH:23][C:22]([Cl:24])=[C:21]([CH2:25][C:26]([NH:6][C@H:5]([C:4]([OH:3])=[O:14])[CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:27])[N:20]1[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[Cl:35])[CH2:16][CH2:17][CH3:18]

Participants

Reactant 3

HCID 75736Methyl L-phenylalaninate hydrochloride

HCID 15280944HCID 15280944, compound

HCID 67858746HCID 67858746, compound

Product 1

HCID 67858636HCID 67858636, compound

Procedure

The title compound is prepared following the procedure of Example 1-(iii-iv) using phenylalanine methyl ester hydrochloride in place of glycine methyl ester hydrochloride and using 2-[n-butyl-1-(2-chlorophenyl)-methyl-4-chloro-1H-imidazol-5-yl]acetic acid (prepared as in U.S. Pat. No. 4,340,598) in place of 1-(2-chlorophenyl)methyl-2 propylthio-1H-imidazole-5-carboxylic acid.

Workup

customprepared as in U.S

Sources & evidence

ORD record: ord-53cdc6fc8384496ba2988f1fd4ac0117
Source dataset: uspto-grants-1993_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05234917

Reaction notes

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