Phenol → HCID 19745034, compound

Participants

Reaction Steps

The synthesis of (A) was carried out as follows. First, sodium 2-chloro-4-nitrobenzenesulfonate and phenol were reacted in water in the presence of a base, to obtain sodium 2-phenoxy-4-nitrobenzenesulfonate. This was reacted with POCl3 /DMAC to produce the sulfonyl chloride form, and then the sulfonyl chloride was reacted with the ethyl ester of glycine, to obtain the carboxylic acid ethyl form of (A). Then it was hydrolyzed followed by reaction with SOCl2 in benzene, and then the benzene was distilled off, so that (A) was obtained in the form of crystals.

Provenance & Evidence