HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 5-(piperazin-1-yl)-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 5-Aminoindole | HCID 78867 | — |
| Reactant | Bis(2-chloroethyl)amine hydrochloride | HCID 522769 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 5-(piperazin-1-yl)-1H-indole | HCID 22174820 | 100% |
Reaction Steps
A solution of 5-aminoindole (6.23 g, 47 mmol), bis(2-chloroethyl)amine hydrochloride (16.8 g, 96 mmol) and triethylamine (19 mL, 141 mmol) in butanol is heated at 100° C. for 8 hours, cooled to room temperature and concentrated in vacuo to give 9.46 g of 5-piperazin-1-yl-1H-indole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07557098B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-a6d51b368a854fdcbe7745b492ae155c |
| Source note | uspto-grants-2009_07 |