反应详情

温度

70 °C

In 50 ml of dichloroethane were dissolved 7.31 g (0.05 mole) of 6-methoxy hexanoic acid and 14.39 g (0.06 mole) of dichloroacetic anhydride. To the resulting solution were added 7.93 g (0.065 mole) of methylenedioxybenzene and 0.71 g of boron trifluoridediethyl ether complex and the resulting mixture was then stirred at 70° C. for 6 hours. After completion of the reaction, the reaction solution was cooled and washed with 5% aqueous sodium carbonate solution and water in this order. The organic layer was concentrated under reduced pressure to obtain 11.2 g of 4-(6-methoxyhexanoyl)-1,2-methylenedioxybenzene.

1. customAfter completion of the reaction
2. temperaturethe reaction solution was cooled
3. washwashed with 5% aqueous sodium carbonate solution and water in this order
4. concentrationThe organic layer was concentrated under reduced pressure