HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 2-(4-acetamidophenoxy)propanoate → Ethyl 2-(4-aminophenoxy)propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 2-(4-acetamidophenoxy)propanoate | HCID 19745458 | — |
| Catalyst | Hydrochloric Acid | HCID 313 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 2-(4-aminophenoxy)propanoate | HCID 11138333 | 95.6% |
Reaction Steps
Ethyl 2-(4- acetamidophenoxy)propanoate (5.0 g, 2.0 mmol) is hydrolyzed by refluxing for 6 hours at 80° C. with ethanol (10 mL) and 3 drops of concentrated hydrochloric acid. The reaction is concentrated under reduced pressure to obtain ethyl 2-(4-aminophenoxy)propanoate (0.4 g) (yield 95%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05235090 |
| Source dataset | uspto-grants-1993_08 |
| ORD ID | ord-d56645549a2a46569c382212b9382428 |
| Source note | uspto-grants-1993_08 |