Chloroacetic Acid → 2-[2,6-Bis(1-methylethyl)phenoxy]acetic acid

Participants

Reaction Steps

16.4 g of 2,6-diisopropylphenol, 10.0 g of chloroacetic acid, 10.0 g of sodium hydroxide and 300 ml of water were put into a round bottom flask and stirred under reflux for 6 hours. The reaction mixture was cooled and then the pH was adjusted to from 3 to 4 with a dilute hydrochloric acid. The precipitate thereby formed was collected by filtration, washed with water and dried to obtain 20.5 g of crude crystals. The crude crystals were recrystallized from diethyl ether-hexane to obtain 19.6 g (yield: 88.3%) of the desired compound as colorless prism crystals. Melting point: 84°-87° C.

Provenance & Evidence