HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2254369Generated: November 2, 2026
Pyridinium chloride → 5-(3-Carboxybenzoyl)-2-hydroxybenzenepropanoic acid
https://huagongshe.com/reaction/2254369
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyridinium chloride | HCID 10176127 | — |
| Reactant | 5-[3-(Ethoxycarbonyl)benzoyl]-2-methoxybenzenepropanoic acid, ethyl ester | HCID 14739655 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-(3-Carboxybenzoyl)-2-hydroxybenzenepropanoic acid | HCID 14739656 | 91.7% |
Reaction Steps
A mixture of 41.5 g of 5-[3-(ethoxycarbonyl)benzoyl]-2-methoxybenzenepropanoic acid, ethyl ester and 410 g of pyridine hydrochloride were heated at 180° C. for 4 hours. After cooling, water was added to the mixture while hot. As the mixture cooled, the title product precipitated from solution. Filtration of the solids and crystallization from ethanol/water provided 31.1 g of the title product, m.p. 197°-200° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05235064 |
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| Source dataset | uspto-grants-1993_08 |
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| ORD ID | ord-bad0d7a613e2484ea1fa4ece42943b82 |
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| Source note | uspto-grants-1993_08 |
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