Sodium borohydride → HCID 19744527, compound

Participants

Reaction Steps

85 mg of the (E)-N-(6,6-dimethyl-2-hepten-4-ynyl)-N-methyl-3-(3-formylbenzyloxy)benzylamine obtained as above was dissolved in 2 ml of ethanol, and under ice cooling, 8.6 mg of sodium borohydride was added with stirring for 30 minutes. The solvent was evaporated under reduced pressure. The residue was dissolved in a mixture of ethyl acetate and water. The organic layer was separated, and dried over anhydrous magnesium sulfate. The desiccant was removed by filtration, and the solvent was evaporated. The residue was purified by silica gel column chromatography (Wakogel C-200, 15 g; eluting solvent: hexane/ethyl acetate=10/1→5/1) to give 40 mg (yield 39%) of the captioned compound as a colorless oil.

Provenance & Evidence