Sodium borohydride → HCID 19744795, compound

Participants

Reaction Steps

228 m9 of 2,4-thiophenedicarboxaldehyde 2-ethylene acetal was dissolved in 3 ml of ethanol, and 57 mg of sodium borohydride was added. The mixture was stirred for 30 minutes at room temperature. The solvent was evaporated, and water and ethyl ether were added to the residue to extract it. The organic layer was separated, and dried over anhydrous magnesium sulfate. The desiccant was separated, and the solvent was evaporated. The residue was purified by silica gel column chromatography Wakogel C-200, 10 g; eluting solvent: hexane/ethyl acetate =1/1] to give 130 mg of 4-hydroxymethyl-2-thiophenecarboxaldehyde ethylene acetal as a colorless oil.

Provenance & Evidence