反应详情

1.6 g of ethyl m-aminobenzoate was dissolved in 10 ml of glacial acetic acid, and 1.3 g of 2,5-dimethoxytetrahydrofuran was added. The mixture was heated under reflux for 2 hours The solvent was evaporated, and the residue was dissolved in ethyl acetate and water. The organic layer was separated and worked up in a customary manner, and finally recrystallized from hexane to give 1.7 g (yield 82%) of purified ethyl 3-(1-pyrrolyl)-benzoate as colorless needles, m.p. 64°-65° C.

1. temperatureThe mixture was heated
2. temperatureunder reflux for 2 hours The solvent
3. customwas evaporated
4. dissolutionthe residue was dissolved in ethyl acetate
5. customThe organic layer was separated
6. customfinally recrystallized from hexane