Hydroxyamine hydrochloride → N-hydroxy-3-(3-methylphenyl)prop-2-yn-1-imine

Participants

Reaction Steps

130 mg of the resulting aldehyde was dissolved in 20 ml of ethanol, and 5 ml of an aqueous solution of 70 mg of hydroxylamine hydrochloride was added. The solvent was evaporated under reduced pressure. The residue was purified by medium-pressure liquid chromatography column: Lobar column, size A, Lichroprep Si 60 (E. Merck Co.); eluting solvent: hexane/ethyl acetate=-10/1] to give 122 mg (yield 85%) of 3-(3-methylphenyl)-2-propynaldehyde oxime as a pale yellow oil.

Provenance & Evidence