Potassium Hydroxide → HCID 57753033, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of {1-[7-(4-bromo-2,6-dimethyl-phenyl)-2,6-dimethyl-thieno[3,2-d]pyrimidin-4-yl]-piperidin-4-yl}-acetonitrile (350 mg) and KOH (492 mg) in a mixture of EtOH (1.5 mL) and H2O (1.0 mL) in a sealed tube was heated at 105° C. for 3 hours. After concentration of the reaction mixture under reduced pressure, 5% KHSO4 aqueous solution was added and extracted with CHCl3. The organic layer washed with brine, dried over anhydrous Na2SO4 and concentrated under reduced pressure. The residue was purified by a silica gel column chromatography (silica gel: Wako Gel (C200), eluent: CHCl3/methanol=20:1) to obtain the title compound (164 mg).

Provenance & Evidence