Methyl 5-bromofuran-2-carboxylate → HCID 19744465, compound

HRID 2254481Notes

Reaction equation

HRID 2254481 reaction equation
COC(C1C=NC=C(Br)C=1)=O.CO[C:14]([C:16]1[O:17][C:18](Br)=[CH:19][CH:20]=1)=[O:15].C(OC([C:27]1[CH:31]=[C:30](Br)[S:29][CH:28]=1)=O)C.S1C=CC(C2C=C(CO)C=NC=2)=C1>>[S:29]1[CH:30]=[CH:31][C:27]([C:18]2[O:17][C:16]([CH2:14][OH:15])=[CH:20][CH:19]=2)=[CH:28]1

Participants

5

Reactant 4

HCID 599633Methyl 5-bromofuran-2-carboxylateHCID 699336Methyl 5-bromopyridine-3-carboxylateHCID 11019666(5-(thiophen-3-yl)pyridin-3-yl)methanolHCID 15293216Ethyl 5-bromothiophene-3-carboxylate

Product 1

HCID 19744465HCID 19744465, compound

Procedure

When the same reaction as in Referential Example 59 is carried out except using 5-bromo-3-pyridine carboxylic acid methyl ester or 5-bromo-2-furancarboxylic acid methyl ester [J. Org. Chem., 21, 517 (1956)] instead of the starting 5-bromo-3-thiophenecarboxylic acid ethyl ester, 5-(3-thienyl)-3-pyridylmethanol or 5-(3-thienyl)-2-furylmethanol is obtained.

Workup

  1. customWhen the same reaction as in Referential Example 59

Sources & evidence

ORD record
ord-f46971d7eda9469fabda5cf446036d05
Source dataset
uspto-grants-1993_08
Patent number
US05234946

Reaction notes

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