Water → HCID 57753035, compound

Participants

Reaction Steps

A mixture of {1-[7-(4-bromo-2,6-dimethyl-phenyl)-2,6-dimethyl-thieno[3,2-d]pyrimidin-4-yl]-piperidin-4-yl}-acetic acid (30 mg), iodoethane (97 mg) and K2CO3 (17 mg) in DMF (1 mL) was stirred at room temperature for 16 hours. To the reaction mixture were added H2O and EtOAc and separated. The organic layer washed brine, dried over anhydrous Na2SO4 and concentrated under reduced pressure. The residue was purified by a silica gel column chromatography (silica gel: Wako Gel (C200), eluent: Hexane/EtOAc=4:1) to obtain the title compound (22 mg) as a white crystal.

Provenance & Evidence