Camphor → Meta-nitrobenzylidenecamphor

Participants

Reaction Conditions

Reaction Steps

The camphor (50.2 g, 0.33 mol), dimethoxyethane (180 ml) and sodium hydride (32 g at 50% in oil, 0.33 mol) washed with dimethoxyethane, are placed in a round-bottom flask. The mixture is heated under nitrogen to 80° C. and the meta-nitrobenzaldehyde (45.3 g, 0.3 mol) dissolved in dimethoxyethane (100 ml) is added dropwise over half an hour. The mixture is left stirring at 80° C. for 1.5 hours. The reaction mixture is allowed to cool and it is poured cautiously in 2 litres of acidified and ice cold water. The brown precipitate obtained is filtered, washed with water and dried. After recrystallisation in diisopropyl ether in the presence of vegetable black, 20 g of meta-nitrobenzylidenecamphor are obtained.

Provenance & Evidence